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Alcohol Metabolism and NADH Pathways

1. This document outlines the pathways of alcohol metabolism and the effects of ethanol processing on cellular metabolism. 2. Key enzymes like ADH, ALDH, CAT and MEOS are involved in ethanol oxidation in the cytosol and peroxisomes, producing acetaldehyde and hydrogen peroxide. 3. The increased NADH produced during alcohol metabolism inhibits various oxidative pathways in the mitochondria by hindering enzymes like PDH, PC and the TCA cycle, altering normal glucose and fat processing.

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pranjl
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10 views5 pages

Alcohol Metabolism and NADH Pathways

1. This document outlines the pathways of alcohol metabolism and the effects of ethanol processing on cellular metabolism. 2. Key enzymes like ADH, ALDH, CAT and MEOS are involved in ethanol oxidation in the cytosol and peroxisomes, producing acetaldehyde and hydrogen peroxide. 3. The increased NADH produced during alcohol metabolism inhibits various oxidative pathways in the mitochondria by hindering enzymes like PDH, PC and the TCA cycle, altering normal glucose and fat processing.

Uploaded by

pranjl
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd

Oh my!

Now what?

Alcohol Metabolism
EtOH
Peroxisome Cytosol
H2O2 ER NAD+
O2
CAT NADPH MEOS ADH
H2 O
P450 Pyrazole
Aminotriazole NADP+ NADH

Acetaldehyde
NAD+ Mitochondrion

AlDH
NADH Disulfiram Chlorpropamide
(antabuse) (diabetes)

Acetate

Extra-hepatic tissue
Eric Niederhoffer
SIU-SOM
Pathway Perturbations
Glc
G6Pase GK
G6P
Cytosol

n
ei
ot
F6P

Pr
F16BPase PFK
Ala
F16BP
Asp
PEPCK
OAA PEP ALT AST
NAD +
NAD+ PK
MDH LDH MDH
Lactate Pyr Malate OAA
NADH NADH NADH
PDH
PC NADH
Acetyl CoA
Malate NAD+
MDH OAA
NADH Cit

Malate
ICit
Mitochondrion
Fum NAD+ IDH
NAD+ NADH
KGDH
Suc KG
S CoA
NADH
Malate-Aspartate Shuttle
(liver, kidney, heart)

IMS Matrix

CI

Asp GT Asp

KG KG
AST AST
Glu Glu

OAA OAA
NADH NADH
MDH MDH
NAD+ NAD+
Mal MT Mal
Glycerol-3-Phosphate
Shuttle
(skeletal muscle, brain)

IMS Matrix

NAD+
G3P
FAD
G3PDH

FADH2
NADH DHAP Q

CIII
Review Questions

How is ethanol detoxified
(enzymes, cofactors, products,
location)?

Which metabolic pathways are
affected by alcohol-derived NADH
(enzymes, metabolites)?

How does the cell process NADH?

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