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Standard Addition Method for Analyte Concentration

This document summarizes the results of a standard additions analysis performed on a chewing gum sample to determine the concentration of an analyte. A linear standard additions plot was obtained, and the point estimate for the analyte concentration in the original sample was calculated to be 48.1 ppm. The standard error of this estimate was calculated to be 0.6 ppm, resulting in a 95% confidence interval of 48.1 ± 2.8 ppm for the analyte concentration in the chewing gum sample.

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Ditta Ria Arini
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11 views1 page

Standard Addition Method for Analyte Concentration

This document summarizes the results of a standard additions analysis performed on a chewing gum sample to determine the concentration of an analyte. A linear standard additions plot was obtained, and the point estimate for the analyte concentration in the original sample was calculated to be 48.1 ppm. The standard error of this estimate was calculated to be 0.6 ppm, resulting in a 95% confidence interval of 48.1 ± 2.8 ppm for the analyte concentration in the chewing gum sample.

Uploaded by

Ditta Ria Arini
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Example: Multiple Standard Addtions

g
sample
3.12 mass of sample, in g
C
std
300.0 conc of added standard, in ppm
V
a
25 volume of sample solutions, in mL
V
std
0 0.1 0.2 0.3 ( )
T
signal 0.214 0.386 0.554 0.728 ( )
T
std addition data
Since all the sample solutions were diluted to the same volume, there is no need to correct the signal for dilution.
Let's take a look at the standard addition plot (to verify linearity).
signal
V
std
0 0.1 0.2 0.3
0
0.5
1
Standard Addition Plot Looks linear; here are the LS estimates
b
0
intercept V
std
signal , b
0
0.2140 =
b
1
slope V
std
signal , b
1
1.7100 =
S
xx
3 Var V
std
.
xbar mean V
std
Point Estimate of Analyte Concentration:
Vprime
b
0
b
1
Vprime 0.1251 = C
a
C
std
Vprime
V
a
.
C
a
1.5018 = concentration in sample
solution, in ppm
g
analyte
C
a
100
.
g
analyte
150.1754 = mass of analyte in chewing gum sample, in ug
(assumes 1 ppm = 1 ug/mL)
conc
g
analyte
g
sample
conc 48.1332 = concentration of analyte in original sample, in ppm
Std Error of Point Estimate, from Residuals
fit b
1
V
std
.
b
0
res signal fit s
res
1
2
res
2
.
s
res
1.7321 10
3
=
s Vprime ( )
s
res
b
1
1
1
4
Vprime xbar ( )
2
S
xx
.
s Vprime ( ) 1.6840 10
3
= std error of Vprime
se
Ca
s Vprime ( )
C
std
V
a
.
se
Ca
0.0202 = std error of solution point estimate, in ppm
se se
Ca
100
g
sample
.
se 0.6477 = standard error of analyte conc estimate in original sample, in ppm
t qt .975 2 , ( ) t 4.3027 = t se
.
2.7868 = width of 95% CI
The concentration of aluminum in the chewing gum is 48.1 2.8 ppm (95% CL)

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