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Standard Deviation in Biochemistry

This document discusses standard deviation (SD), a measure of dispersion used in statistical analysis. SD is calculated by taking the square root of the variance, which is the mean of the squared deviations from the mean. SD summarizes how much variation there is from the average and indicates whether differences from the mean are due to chance. It helps determine whether differences between means of samples are significant. The standard normal curve is a perfectly symmetrical bell-shaped curve with a mean of 0 and SD of 1. About 68% of values in a normal distribution fall within 1 SD of the mean and 95% fall within 2 SDs.

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Dr. M. Prasad Naidu
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32 views17 pages

Standard Deviation in Biochemistry

This document discusses standard deviation (SD), a measure of dispersion used in statistical analysis. SD is calculated by taking the square root of the variance, which is the mean of the squared deviations from the mean. SD summarizes how much variation there is from the average and indicates whether differences from the mean are due to chance. It helps determine whether differences between means of samples are significant. The standard normal curve is a perfectly symmetrical bell-shaped curve with a mean of 0 and SD of 1. About 68% of values in a normal distribution fall within 1 SD of the mean and 95% fall within 2 SDs.

Uploaded by

Dr. M. Prasad Naidu
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd

M.

Prasad Naidu
MSc Medical Biochemistry, Ph.D,.

It is an improvement over mean deviation

Measure of dispersion

Used most commonly in statistical analyses


Calculation of SD

First find the mean of series

Find the deviation or difference of individual


measurement from mean

Next find the sum of squares of deviation or


difference of individual measurements from their
mean

Now find the variance (Var) mean squared


deviation

var ! (" # ")
$
% n

If lar&e sample si'e (

If sample less than )* (


Square root of variance that gives SD
For ex :
Mean = 2+5+3+4+15 = 155 = 3
!ar = 1"5 = 2
#ses of SD

It summari'es the deviation of a lar&e distri+ution from


mean in one fi&ure used as unit of variation

Indicates whether the variation of difference of an


individual from mean is +y chance

,elps in findin& the -. which determines whether the


difference +etween means of two similar samples is +y
chance or real

,elps in findin& the suita+le si'e of sample for valid


conclusion/

0he shape of curve will depend upon mean and -1 of which


in turn depend upon the num+er and nature of o+servation/

In normal curve (#

2rea +%w 3 -1 on either side of mean will include


approximately 456 of values in distri+ution

2rea +%w $ -1 is 786

2rea +%w ) -1 is 77/96

0hese limits on either side of mean are called :confidence


limits;
SD of nor$al curve
Stan%ar% nor$al curve

-mooth

+ell shaped

<erfectly symmetrical

=ased on infinity lar&e num+er of o+servation

0otal area of curve 3

Mean *

-1 3

Mean > median and mode all coincide


SD of nor$al curve

=ell shaped curve will show an inflexion on the ascendin&


as well as descendin& units of curve

If vertical lines are drawn from each of these points they


will intersect the " axis on either side of the mean at an
equal distance from it

2 lar&e portion of area under the normal curve has +een


included in portion of curve +%w the $ points of inflexion

0he distance +%w the mean and point of inflexion


either side is equal to -1 and is denoted +y a ? si&n
prefixed to it to indicate that it extends on either side
of mean/

If another vertical line is drawn an either side of mean


at a distance equal to twice -1 most of values in
distri+ution ta+le would have +een included in this
part of curve

In most cases> ? -1 will include $%) of sample values


and mean ? $ -1 will include 7*6 of values/

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