Saath
Hew wiu you stou daug metaboliam Haough pathuways
Bictuaushsmation oh dugs basjcally occus A phases
Phase 1 veachions (Non-yntehic)
Phase zacions (Suyntrehic)
chenical alleration of daug in body that cohyeeda
non-polas/lipid Soluble ompoundX to polan/iptd
nsouble. campounmds:
Phdse
ApOse ad
Xenobichic Forchional 92 Pumau Conugat an 2 Prutuct
(dngs Paoduct
peshadset Oxidaham
Reduchoh
Hydolyeis exAdhon
papilic Hydaopili c
Dsuugs can be mebabolizadH Oxidahon, xeduchion, heolei,
kdhahan,ConjugaioHCOudensation
whaken the
or izomeaizationj
pavcass qoal fo make daug _easies o extzefe
tabolils umed Aunthetic. gkM AA moia polaA
ws maao. "hsadil ex olckd by
- w[ m bile juau hose eicneys in uone)
fomed hon=-
kynhetie n .
Renal SnAchiau o Duugk
okidueyg aue. Helponsible au he enrlhOn a neasdy
all duugs as well as theis, metabalites , to a wtn eylet
ponible. losu the cnuetiou
soute , excsiMely
Renal
o&ce doungs , like qntamicin
wakes oluble, non -yvlatile , Small moleulan size
agent& that undesgo low melabolism,
(4500 daltons)
via Uuna.
ndeng0 extion
OAlomevulas1 filtesation
of walen unbouud dkugs qlomeu
metaboli le3.
Achue TLbulas Seodjeu bProkmae
acidic baic dougk )ub LBlovd
of
*meBaboli les .
Actu Reahsoupfiou LeoP
Henl
of acidic x basic edoqenous
Compounds passine
uabsouptian af lipophilie a) Coldechng
Tubule
duuus
metabotiles that aue hilterad
U3iasy excetioy of deugs k
not keabsaxbed.
aud d aciuely Secited
Nephaon Baic tuMCHOvaut q Kidney , nvvluad in exoaion.
exLtion =
Rake of +Rale q - Rale 4
Rake o iaion exowi an Reabsauption
taclo leting RLnal eauuha
oq. Dguugs. 3
Phuysicochomical [Link] of baug
) easily exoule out)
(Smallyt mole culan
a) Molecula9. w aaiy eaee ouk)
(Hyduopkilie dougs
5) ipid svubility
V4
c)Valume. aof. Disøubuhio
2 Reval Blead Plow
PeuhsAon
> 1 exuhion.
dsus
3) binding chasaclenushics 4 Duu Clomerulus (whidh aue to
FiLlenatiou not powible 'hy plasma pavkin)
magDmolecules
hey q4 as
Renal caasanco
4 Duug unal clearante,
In cake
impajud
shoug toxic
leuels ef d
NOUdas * bady
o* sg
Coyceutyaion
Plasma dsug
5 wt prvle
bound,
dsug
u
Rllknaion d PlauMa COnc
Gilo mnulasu guabsouption,
glomoulasu lsale
gaua
In dougt
shouring
only COMc n
whem
exouh on occs
thau aabsoopiau capacity.
. nigho
GU4ine Pr M
e x o u i On occUB wakly acidic douugs
Uith
Lnguahd wwg..
basic druas n qudic
bae
ue ,
* waaRly
Biological
actou (Age,Sex ee.)
8) Pugnan
inla chion
) iDauty
D 9ease states
Date Saathi
&Kenal cleamam Nen-Renal Cleasante.
Kual cleaiane. is he. velue, plasma Corpufely ceaisd
aSuhstuna. by Hhe kidney peh unit lime
Ncn-feat cleasan Ce, t . aygregeade a l l douug
meual pcsthwauys exdluling fhose
Selated te Hhe kidluya
nepaje, puwima y infeshinal
Ka cloaiau ogang usponi ble. fosnal clharAnR
Saue
Rualcleasane ( lR)
= Rale d elimation by icdnoy
Plaia daug cocn
Tatal bady Cleaanta s sun a Mdjvcea. cleasanas by
al elimiaing ogans-
RuMal
No- Cleaance ae
0qans ulpayble r
also Lalla d enlesohepatic eaatjon
dene by hapatic. cells of luue
Pulmeuait
dove by ung
Sin ple. uion ooceAs
3Salivay eCALIOn
passniue dion pova baud on pH-pashhion kupceis
do Hhooug saliva
Date
Saathy
4amaky exUchion
metabolle ufo
exthetion al diug -}uei1
milk
pasiw puces
Skndesimal exaehion
S t Exsoled thavugh skun Via sua
o
tollsws pH pahtien hypethastz
I exathon_
oexuaien daugg into GI7T
0
alfes paknteaal edmunsfsati &s
Occus
opamu dilhusion
oeneA ef"GI aubsoaptiom damgg
Cnenilal exiehen
2liminaled 7a Kapuduchiue bact &
-euial ufe
Oso eli minaled via laujmal Pluid